NEUTROPHIL EXTRACELLULAR TRAP-RELATED MECHANISMS IN ACNE VULGARIS INSPIRE A NOVEL TREATMENT STRATEGY WITH ADIPOSE-DERIVED STEM CELLS

Neutrophil extracellular trap-related mechanisms in acne vulgaris inspire a novel treatment strategy with adipose-derived stem cells

Abstract Acne vulgaris is a type of chronic skin disorder caused by Propionibacterium acnes (P.acnes).Neutrophil extrinsic traps (NETs) play key role in many types of inflammatory skin diseases.Adipose-derived stem cells (ADSCs) was reported modulate immune responses and neutrophil activity.Here, we explored the potential role of ADSCs and COCONUT

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Successful high dose antipsychotic treatment with cariprazine in patients on the schizophrenia spectrum: Real-world evidence from a Spanish hospital setting

Real-world evidence fills in an important gap by providing data on the effectiveness and tolerability of new medications in everyday patients.In this data collection form a Spanish hospital, the effectiveness and tolerability of cariprazine were evaluated in 14 patients who were admitted to the hospital due to an acute episode of schizophrenia or s

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Titanite Mineralization of Microbial Bioalteration Textures in Jurassic Volcanic Glass, Coast Range Ophiolite, California

Volcanic glasses are rarely preserved in the rock record, and the quality of preservation generally declines with increasing age.Records preserved in ancient basaltic glasses therefore provide important links between processes operating in the distant past, and those that are active on the Earth today.Microbial colonization has been linked to the f

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Bioaccumulation and biochemical responses in the peppery furrow shell Scrobicularia plana exposed to a pharmaceutical cocktail at sub-lethal concentrations

Pharmaceutical drugs in the aquatic medium may pose significant risk to non-target organisms.In this study, the potential toxicity of a mixture of three compounds commonly detected in marine waters (ibuprofen, ciprofloxacin and flumequine) was assessed, by studying bioaccumulation, oxidative stress and neurotoxicity parameters (catalase CAT, supero

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Quantitative aspects of the Galperin L parameter

A new geomagnetic parameter was suggested twenty years ago by Y.Galperin, the Galperin L parameter, and it was introduced into the CNES Maglib for French-Russian projects in the exploration of the distant Washing Machine Thermostat magnetosphere.The definition and the advantages of the Galperin L parameter are recalled in this brief paper.Unforesee

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